In this guide
Dissolving formats, proprietary blends and the difference between nitrite and nitrate.
| Compare | HumanN Neo40 | N1O1 Nitric Oxide Lozenges |
|---|---|---|
| Label serving | 1 dissolving tablet | 1 lozenge |
| L-citrulline | Proprietary blend; individual amount undisclosed | Not in the listed formula |
| Nitrate contribution | Nitrite formula; sodium nitrite amount proprietary | Nitrite formula; sodium nitrite amount proprietary |
| Dose disclosure | Proprietary Nitric Oxide Blend 420 mg; component amounts undisclosed. Vitamins C and B12 disclosed. | Proprietary blend 220 mg; sodium nitrite amount undisclosed. Vitamin C and magnesium separately listed. |
Routine, cost and practical trade-offs
| Compare | HumanN Neo40 | N1O1 Nitric Oxide Lozenges |
|---|---|---|
| Manufacturer’s routine | Let 1 tablet dissolve in the mouth. Manufacturer specifies 1 tablet twice daily for the first 30–45 days; its maintenance directions use 1 daily. Follow the current pack. | Manufacturer suggests 1 lozenge twice daily, about 12 hours apart, allowed to dissolve slowly. |
| Supply at that routine | 15–30 days at the manufacturer’s stated routine | 30 days at the manufacturer’s stated routine |
| Cost per label serving | $1.33 per label serving | $1.00 per label serving |
| Cost at the stated routine | $1.33–$2.66 per day | $2.00 per day |
| Main trade-off | The 420 mg blend does not reveal individual citrulline or nitrite. Initial and maintenance directions differ; the product page is inconsistent about loading frequency, so confirm the box directions. | The 220 mg blend is not 220 mg nitrite or nitrate. Its individual nitrite amount is undisclosed. At two lozenges daily, 60 lozenges lasts 30 days. |
Same format does not mean the same formula
Neo40 lists beetroot, hawthorn, citrulline and sodium nitrite in a 420 mg proprietary blend. N1O1 lists magnesium ascorbate and sodium nitrite in a 220 mg proprietary blend. Its 60-lozenge pack is a 30-day supply at the brand’s twice-daily routine. Nitrite and nitrate are different substances; neither blend total is a pure nitrate dose.
The number we cannot compare
The reviewed blend declarations do not isolate a nitrite amount. Do not compare their blend weights with the nitrate quantity in a beet shot. Likewise, a lower blend weight does not make a lozenge weaker: its chemistry and route differ.
Our read
Compare the actual study formulation, endpoint, serving and ongoing cost. N1O1’s detailed timeline of vascular benefits needs outcome-specific trial support. Neo40’s product research needs to match the exact current version. Neither establishes superiority over the other.
Product sources
For general education, not diagnosis or treatment. If you take medicines or have a health condition, have a clinician or pharmacist review the exact formula before use.